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A brief overview of some hormonal effects on male and female sexual behaviors and thoughts

1998 by Rainer Stratkotter

 

Introduction

For both males and females, various hormones can have "effects" on their sexual behaviors and thought

    Among these hormones, androgenic hormones - such as testosterone (T) and dihydrotestosterone (DHT) - are especially noted for their ability to "increase the predisposition to engage in sexual behavior." (Udry, 1988, p. 710). This increased predisposition towards sexual behavior is believed to be linked with hormonally effected changes in the patterning (frequency, intensity, and duration) of sexual thoughts (e.g., sexual interests, motivations, attitudes, and fantasies).

    The first section below deals with males, with its main focus on androgenic hormones' effects on sexual behaviors and thoughts (along with some mention of other hormones' effects). The second section deals with hormonal effects on females' sexual behavior and thoughts.

Hormonal effects on male sexual behaviors and thoughts

The view that there is a hormonal basis for sexual behaviors and thoughts is supported by "ample evidence" (Frayser, 1985, p. 12; see also Robbins, 1996), including evidence obtained from male adolescents (Udry, Billy, Morris, Groff, and Raj, 1985). Testosterone, which is an androgenic hormone, generally appears to be a dominant factor in male sexual libido and ejaculation, while erectile mechanisms can function despite abnormally low levels of T (Bancroft, 1984; Buvat, Lemaire, and Ratajczyk, 1996).

Although it is not certain what levels of the various androgens produce maximum effects on the various aspects of sexuality, studies which provide T to hypogonadal men suggest that above a certain threshold, increased T levels have no further effects (Sherwin, 1988). Since normal adult males' androgen levels are above the threshold, adult males are poor subjects for investigating the effects of androgens on sexuality (Udry, 1988, p. 711). In this regard, adolescent males are good subjects, as early adolescents can be considered to be analogous to hypogonadal adult males, except that normal pubertal development of the adolescents will remedy their androgen deficit (p. 711).

According to Udry, T is the "most behaviorally potent" androgen (Udry, 1990, p. 2; see also Udry, 1988, p. 713); although it is generally accepted that T's androgenic potency results from its conversion (by the 5a-reductase enzyme) to dihydrotestosterone (DHT) (Gower, 1995, p. 269; see also Norman and Litwack, 1987, p. 492; Demers, 1995, p. 28). Males with higher levels of T will generally also have higher levels of DHT.

[There are "intracellular receptors that bind testosterone and DHT with high affinity" (Winters, 1995, p. 1053), but "it has not been possible to unequivocally determine in which tissues which steroid [T or DHT] is the primary or sole initiator" (Norman and Litwack, 1987, p. 495). Hence, there is continued debate over whether T or DHT is the effectually most potent androgen, with support for either position dependent on the biological location in question (Mitchell, 1996, personal communication).]

Many of T's other actions depend on its metabolism, by an aromatase enzyme, to estradiol (Collaer and Hines, 1995, p. 57).

Of the total circulating T (Total-T) in normal men, "less than 4% is free (not protein bound), 1% to 2% is bound to cortisol binding globulin, about 40% is loosely bound to albumin, and the remainder is bound with high affinity to the b-globulin, SHBG" (Winters, 1995, p. 1050; this report conflicts with Udry's assertion that "Nine-tenths or more of T is so bound [to SHBG]", 1990, p. 3). Although "the function of SHBG remains controversial" (Winters, 1995, p. 1050), T effects should be interpreted in conjunction with SHBG effects, and should be the opposite of SHBG effects (Udry, 1988).

[Winters reports that "the finding of membrane binding sites for ABP (androgen binding protein) in the epididymis and for SHBG in testis ... suggests that these binding proteins" might be directly involved in androgen action (1995, p. 1050).]

The T that is unbound to SHBG is commonly termed Free-Testosterone (Free-T), and is believed to be the portion of the total amount of T able to act on receptor cites (directly or via T's metabolites, such as DHT and estradiol), thereby influencing behaviors and thoughts (Nieschlag, 1979; Udry, 1988). The Free-T level has been reported to be between about 1 and 2.5 or 3 percent of Total-T's level (Winters, 1995, p. 1051; see also Schurmeyer and Nieschlag, 1984); although higher percentages have been reported (e.g., Hammond, Nisker, Jones, and Siiteri, 1980, estimated that Free-T comprises 2 to 8 percent of Total-T).

There is a mixed use of the "Free-T" terminology in the literature. Some researchers make a clear distinction between "Free-T" and "bioavailable (non-SHBG bound) T" (e.g., Buvat, Lemaire, and Ratajczyk, 1996), while others do not (e.g., Udry, 1990; Christiansen and Winkler, 1992); and the term "Apparent Free Testosterone Concentration (AFTC)" also appears (e.g., Hjalmarsen, Aasebo, Aakvaag, and Jorde, 1996). The Free-T plus the albumin-bound T have been referred to as the non-SHBG-bound T (e.g., Gower, 1995, p. 337; Winters, 1995, p. 1051).

The albumin-bound T, because of the low-affinity binding constant, is thought to be as readily available to target tissues as is Free-T, hence "bioavailable testosterone is calculated by subtracting the SHBG bound testosterone from the total testosterone level" (Winters, 1995, p. 1051).

The Free-T index, which is calculated either as the Total-T / SHBG ratio, or as (Total-T)(SHBG) / (mean normal SHBG level), are ways "to correct the total testosterone value for variations in SHBG concentrations in plasma" (Winters, 1995, p. 1051). The Free-T index is believed to be a good indicator of measured Free-T; and is considered to be a better indicator of androgenicity than Total-T (Halpern, Udry, Campbell, Suchindran, and Mason, 1994, p. 221).

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References and some suggested reading

Bancroft, John (1984). Hormones and human sexual behavior. Journal of Sex and Marital Therapy, 10: 3-21.

Becker, Kenneth L. (Ed.) (1995). Principles and Practice of Endocrinology and Metabolism. Philadelphia: J.B. Lippincott Company.

Bogaert, Anthony F; & Fisher, William A. (1995). Predictors of university men's number of sexual partners. Journal of Sex Research, 32(2): 119-130.

Bouchard, Jr., Thomas J.; Lykken, David T.; McGue, Matthew; Segal, Nancy L.; & Tellegen, Auke. (1990). Sources of human psychological differences: The Minnesota study of twins reared apart. Science, 250: 223-228.

Butler, G.E.; Walker, R.F.; Walker, R.V.; Teague, P.; Riad-Fahmy, D.; & Ratcliffe, S.G. (1989). Salivary testosterone levels and the progress of puberty in the normal boy. Clinical Endocrinology, 30(5): 587-596.

Buvat, J.; Lemaire, A.; & Ratajczyk, J. (1996). Role of hormones in sexual dysfunctions, homosexuality, transsexualism and deviant sexual behavior: Diagnostic and therapeutic consequences: A review. Contraception, Fertilite, Sexualite, 24(11): 834- 846.

Christiansen, Kerrin; & Winkler, Eike-Meinrad (1992). Hormonal, anthropometrical, and behavioral correlates of physical aggression in !Kung San men of Namibia. Aggressive Behavior, 18: 271-280.

Coe, Christopher L.; Hayashi, Kevin T.; & Levine, Seymour (1988). Hormones and behavior at puberty: Activation or concatenation? In Megan R. Gunnar and W. Andrew Collins (Eds.), Development During the Transition to Adolescence, The Minnesota Symposia on Child Psychology, Vol. 21. Hillsdale, New Jersey: Lawrence Erlbaum Associates Publishers. Pp. 17-41.

Collaer, Marcia L.; & Hines, Melissa (1995). Human behavioral sex differences: A role for gonadal hormones during early development? Psychological Bulletin, 118(1): 55-107.

Couwenbergs, C.; Knussmann, R.; & Christiansen, K. (1986). Comparisons of the intra- and inter-individual variability in sex hormone levels of men. Annals of Human Biology, 13(1): 63-72.

Dabbs, Jr., James M. (1992). Testosterone and occupational achievement. Social Forces, 70(3): 813-824.

Demers, Laurence M. (1995). Biochemistry and laboratory measurement of androgens in women. In G.P. Redmond (Ed.), Androgenic Disorders. New York: Raven Press. Pp. 21-34.

Eysenck, Hans J. (1991). Dimensions of personality: The biosocial approach to personality. In Jan Strelau and Alois Angleitner (Eds.), Explorations in Temperament: International Perspectives on Theory and Measurement - Perspectives on Individual Differences. New York: Plenum Press. Pp. 87-103.

Frayser, Suzanne G. (1985). Varieties of Sexual Experience: An Anthropological Perspective on Human Sexuality. New Haven, Connecticut: HRAF Press.

Gould, Stephen Jay (1976). Biological potential vs. biological determinism (reprinted from Natural History Magazine, May, 1976). In Arthur L. Caplan (1978) (Ed.), The Sociobiology Debate: Readings on Ethical and Scientific Issues. New York: Harper & Row, Publishers, Inc.

Gower, D.B. (1995). Extraction, purification and estimation of the androgens and their derivatives. In H.L.J. Makin, D.B. Gower, and D.N. Kirk (Eds.), Steroid Analysis. Glasgow: Blackie Academic and Professional.

Halpern, Carolyn Tucker; & Udry, J. Richard (1992). Variation in adolescent hormone measures and implications for behavioral research. Journal of Research on Adolescence, 2(2): 103-122.

Halpern, Carolyn Tucker; Udry, J. Richard; Campbell, Benjamin; Suchindran, Chirayath; & Mason, George A. (1994). Testosterone and religiosity as predictors of sexual attitudes and activity among adolescent males: A biosocial model. Journal of Biosocial Science, 26(2): 217-234.

Hammond, G.L.; Nisker, J.A.; Jones. L.A.; & Siiteri, P.K. (1980). Estimation of the percentage of free steroid in undiluted serum by centrifugal ultrafiltration-dyalysis. Journal of Biological Chemistry, 255: 5023-5026.

Hjalmarsen, A.; Aasebo, U.; Aakvaag, A.; & Jorde, R. (1996). Sex hormone responses in healthy men and male patients with chronic obstructive pulmonary disease during an oral glucose load. Scandinavian Journal of Clinical and Laboratory Investigation, 56(7): 635-640.

Horton, Richard (1995). Testicular steroid transport, metabolism, and effects. In Kenneth L. Becker (Ed.), Principles and Practice of Endocrinology and Metabolism. Philadelphia: J.B. Lippincott Company. Pp. 1042-1047.

Kalichman, S.C.; & Rompa, D. (1995). Sexual sensation seeking and sexual compulsivity scales: Reliability, validity, and predicting HIV risk behaviors. Journal of Personality Assessment, 65(3): 586-601.

Kinsey, Alfred C.; Pomeroy, Wardell B.; & Martin, Clyde E. (1948). Sexual Behavior in the Human Male. Philadelphia: Saunders.

Knussmann, R.; Christiansen, K.; & Couwenbergs, C. (1986). Relations between sex hormone levels and sexual behavior in men. Archives of Sexual Behavior, 15(5): 429-445.

Lee, Peter A. (1995). Physiology of puberty. In Kenneth L. Becker (Ed.), Principles and Practice of Endocrinology and Metabolism. Philadelphia: J.B. Lippincott Company. Pp. 822-830.

Levine, Stephen B. (1992). Sexual Life: A Clinician's Guide. New York: Plenum Press.

Libet, Benjamin. (1996). Neural processes in the production of conscious experience. In Max Velmans (Ed.), The Science of Consciousness: Psychological, Neuropsychological and Clinical Reviews. London: Routledge. Pp. 96-117.

Matsumoto, Alvin M. (1995). Clinical use and abuse of androgens and antiandrogens. In Kenneth L. Becker (Ed.), Principles and Practice of Endocrinology and Metabolism Philadelphia: J.B. Lippincott Company. Pp. 1110-1123.

McCabe, M.P.; & Collins, J.K. (1983). The sexual and affectional attitudes and experiences of Australian adolescents during dating: The effects of age, church attendance, type of school, and social economic class. Archives of Sexual Behavior, 12(6): 525-539.

Mitchell, Peter (1996). Personal communication. (At the time of this reference, Dr. Peter Mitchell was the chair of the Department of Obstretics and Gynaecology, Royal Alexandra Hospital, Edmonton, Alberta, Canada.)

Nevid, Jeffery S.; Fichner-Rathus, Lois; and Rathus, Spencer A. (1995). Human Sexuality in a World of Diversity. Boston: Allyn and Bacon.

Nieschlag, E. (1979). The endocrine function of the human testis with regard to sexuality. In Ruth Porter and Julie Whelan (Eds.), Sex, Hormones and Behaviour. Amsterdam: Excerpta Medica. Pp. 183-208.

Norman, Anthony W.; & Litwack, Gerald (1987). Hormones. Orlando: Academic Press, Inc.

Pleck, Joseph H.; Sonenstein, Freya L.; & Ku, Leighton C. (1993). Masculinity ideology: Its impact on adolescent males' heterosexual relationships. Journal of Social Issues, 49(3): 11-29.

Plomin, Robert; Owen, Michael J.; & McGuffin, Peter (1994). The genetic basis of complex human behaviors. Science, 264: 1733-1739.

Redmond, Geoffrey P. (Ed.) (1995). Androgenic Disorders. New York: Raven Press.

Robbins, Ann (1996). The effects of hormones on male sexuality: Findings from clinical trials on male contraception. In Sondra Zeidenstein and Kirsten Moore (Eds.), Learning About Sexuality: A Practical Beginning. New York: The Population Council, Inc. Pp. 278-297.

Rossi, Alice S. (1994). Eros and caritas: A biopsychosocial approach to human sexuality and reproduction. In Alice S. Rossi (Ed.), Sexuality Across the Life Course. Chicago: The University of Chicago Press. Pp. 3-36.

Schurmeyer, T.; & Nieschlag, E. (1984). Salivary and serum testosterone under physiological and pharmacological conditions. In G. Read (Ed.), Immunoassay of Steroids. Cardiff, England: Alpha Omega Publishing. Pp. 202-209.

Schuster, M.A.; Bell, R.M.; & Kanouse, D.E. (1996). The sexual practices of adolescent virgins: Genital sexual activities of high school students who have never had vaginal intercourse. American Journal of Public Health, 86(11): 1570-1576.

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Thornton, Arland; & Camburn, Donald (1987). The influence of the family on premarital sexual attitudes and behavior. Demography, 24: 323-340.

Udry, J. Richard (1988). Biological predispositions and social control in adolescent sexual behavior. American Sociological Review, 53: 709-722.

Udry, J. Richard (1990). Biosocial models of adolescent problem behaviors. Social Biology, 37(1-2): 1-10.

Udry, J. Richard (1992). The study of adolescent sexual behavior, Tallahassee: Hormone supplement (Data Set I1), Kaplan, A.S.; Lang, E.L.; & Card, J.J. (Archivists), [machine-readable data file and documentation]. Chapel Hill: Carolina Population Center (Producer). Los Altos, California: Sociometrics Corporation, Data Archive on Adolescent Pregnancy and Pregnancy Prevention (Producer and Distributor).

Udry, J. Richard (1995). Sociology and Biology: What Biology Do Sociologists Need to Know? Social Forces 73(4): 1267-1278.

Udry, J. Richard (1996). Personal communication (via electronic mail).

Udry, J. Richard; & Billy, John O.G. (1987). Initiation of coitus in early adolescence. American Sociological Review, 52(6): 841-855.

Udry, J. Richard; Billy, John O.G.; Morris, Naomi M.; Groff, Terry R.; & Raj, Madhwa H. (1985). Serum androgenic hormones motivate sexual behavior in adolescent boys. Fertility and Sterility, 43: 90-94.

Udry, J. Richard; Morris, Naomi M.; & Kovenock, Judith (1995). Androgen effects on women's gendered behaviour. Journal of Biosocial Science, 27(3): 359-368.

Udry, J. Richard; Talbert, Luther M.; & Morris, Naomi M. (1986). Biosocial foundations for adolescent female sexuality. Demography, 23: 217-230.

van Haaren, Frans. (1993). Methods in Behavioral Pharmacology. New York: Elsevier.

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Winters, Stephen J. (1995). Evaluation of testicular function. In Kenneth L. Becker (Ed.), Principles and Practice of Endocrinology and Metabolism. Philadelphia: J.B. Lippincott Company. Pp. 1048-1056.

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