It has been theorized that multi-nucleation might explain the longstanding anecdotal phenomenon most athletes call "muscle memory".
Muscle memory is recognized when someone who has had substantial muscular mass and then lost it due to injury or layoffs from training, returns to training and regains the majority of the mass in a much shorter time than was initially required to develop it.
What could be happening is that the specific muscle proteins in the muscle were cannibalized by the body for energy production during non-use. The muscle, however, retains a higher than average number of nuclei that the previous exercise stress caused the body to create.
When presented with exercise and proper nutrients, new protein synthesis can occur at an accelerated rate.
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